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Your diagnosis

Mutations and other DNA changes in NSCLC

Alterations 

Some people with NSCLC have a change in their DNA that causes their cancer to start growing. These changes can include things like ‘mutations’ (where a small bit of the DNA changes) and ‘fusions’ of different parts of your DNA (where two different pieces of DNA stick together incorrectly). These changes are given names based on what part of the DNA they happen in. Some examples of this are ALK+, RET+, and ROS1+ NSCLC.

Click on one of the options below to learn more about these types of NSCLC, including who they typically affect and what having one of these types of NSCLC might mean for you.

ALK

ALK

Learn more about ALK+ NSCLC and what this means for you.
RET

RET

Discover what RET+ NSCLC means and what impact it might have on your NSCLC.
ROS1

ROS1

Learn what causes ROS1+ NSCLC and how this might affect you.
Symptoms

Symptoms

NSCLC can cause lots of different symptoms. Here, we tell you a bit more about these and give you some advice on how to manage them.
Click here to view the glossary
ALK
Anaplastic lymphoma kinase
DNA
Deoxyribonucleic acid
NSCLC
Non-small cell lung cancer
RET
Rearranged during transfection
ROS1+
C-ros oncogene 1